Reaktion #86333

Reaktionsgleichung

5-bromopyridine-2-sulfonyl chloride hydrochloride

2-aminoethanol

Et3N

→

title compound

5-bromo-N-(2-hydroxyethyl)pyridine-2-sulfonamide

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a 4 mL vial equipped with a magnetic stir bar
2. 2
   SonstigeThe reaction mixture was subsequently partitioned between water (10 mL) and ethyl acetate (15 mL)
3. 3
   SonstigeThe layers were separated
4. 4
   Extraktionthe aqueous layer was back-extracted with ethyl acetate (15 mL)
5. 5
   EinengenThe combined organic layers were concentrated

Vorschrift

In a 4 mL vial equipped with a magnetic stir bar were combined 5-bromopyridine-2-sulfonyl chloride hydrochloride (50 mg, 0.171 mmol), 2-aminoethanol (0.015 mL, 0.256 mmol), Et3N (0.071 mL, 0.512 mmol), and acetonitrile (1 mL). The resulting yellow solution stirred at room temperature overnight. The reaction mixture was subsequently partitioned between water (10 mL) and ethyl acetate (15 mL). The layers were separated and the aqueous layer was back-extracted with ethyl acetate (15 mL). The combined organic layers were concentrated to give the title compound as a clear liquid, which was used without further purification (55 mg).

Quelle