Reaktion #8625

Reaktionsgleichung

water

Imidazole

homoserine

tert-Butyldimethylsilyl chloride

→

2-amino-4-(tert-butyldimethylsilanyloxy)butyric acid

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONadded
2. 2
   workup.STIRRINGthe mixture is stirred for ten minutes at 0° C. the for 4 hours at room temperature
3. 3
   Filtrationthe resulting solid is collected by filtration
4. 4
   SonstigeThe isolated product is dried
5. 5
   Sonstigeused without further purification

Vorschrift

Imidazole (20.4 g, 300 mmol) is added to a solution of homoserine (11.9 g, 100 mmol) in DMF (100 mL) and the solution is stirred 15 minutes then cooled to 0° C. tert-Butyldimethylsilyl chloride (13.7 g, 91 mmol) added and the mixture is stirred for ten minutes at 0° C. the for 4 hours at room temperature. The reaction mixture is poured into water (3 L) and the resulting solid is collected by filtration. The isolated product is dried and used without further purification.

Quelle