Reaktion #86242

Reaktionsgleichung

2-bromo-6-fluoropyridine

1,4-diazepan-6-ol

DIPEA

→

1-(6-Bromopyridin-2-yl)-1,4-diazepan-6-ol

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion of the reaction, it
2. 2
   Einengenwas concentrated under reduced pressure
3. 3
   SonstigeThe crude material was used in the next step without further purification

Vorschrift

To a mixture of 2-bromo-6-fluoropyridine (845 mg, 4.83 mmol) and 1,4-diazepan-6-ol (560 mg, 4.83 mmol) in EtOH (20 mL) was added DIPEA (5 mL). The reaction mixture was heated at 100° C. for 15 hours, which was monitored by LCMS. After completion of the reaction, it was concentrated under reduced pressure. The crude material was used in the next step without further purification. MS (ESI) m/z: 272 [M+H]+.

Quelle