Reaktion #86069

Reaktionsgleichung

3-cyclopentyl-3-oxo-propionitrile

hydrazine hydrate

→

5-cyclopentyl-2H-pyrazol-3-ylamine

Ausbeute 46.2%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas evaporated to dryness
2. 2
   SonstigeThe residue was purified by flash chromatography

Vorschrift

To a solution of 3-cyclopentyl-3-oxo-propionitrile (1.0 g, 7.3 mmol, 1 eq) in ethanol (10 mL) was added a 64 wt.-% solution of hydrazine hydrate (1.1 mL, 14.6 mmol, 2 eq). The mixture was heated at 80° C. for 16 h and was evaporated to dryness. The residue was purified by flash chromatography using dichloromethane and methanol (100/0 to 90/10) to afford 5-cyclopentyl-2H-pyrazol-3-ylamine as yellow oil (510 mg, 46% yield).

Quelle