Reaktion #86040

Reaktionsgleichung

2-amino-3-bromopyridine

ethoxycarbonyl isothiocyanate

→

ethyl [(3-bromopyridin-2-yl) carbamothioyl]carbamate

Ausbeute 100.1%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigedichloromethane was removed in vacuo

Vorschrift

To a solution of 2-amino-3-bromopyridine (50.0 g, 289 mmol, 1 equiv) in dichloromethane (500 mL) was added dropwise ethoxycarbonyl isothiocyanate (39.0 g, 297 mmol, 1.03 equiv) at room temperature. After 2 h, dichloromethane was removed in vacuo to provide crude ethyl [(3-bromopyridin-2-yl) carbamothioyl]carbamate (88 g).

Quelle