Reaktion #85900

Reaktionsgleichung

(S)-tert-butyl 3-acetylpyrrolidine-1-carboxylate

sodium borohydride

→

title compound

(S)-tert-butyl 3-(1-hydroxyethyl)pyrrolidine-1-carboxylate

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethen quenched with saturated ammonium chloride solution
2. 2
   Extraktionextracted with dichloromethane
3. 3
   TrocknenThe combined extracts were dried over magnesium sulfate
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated

Vorschrift

To a solution of (S)-tert-butyl 3-acetylpyrrolidine-1-carboxylate in methanol (10 mL) was added sodium borohydride (114 mg, 3.0 mmol) at 0° C. The reaction mixture was stirred at ambient temperature for 2 hours then quenched with saturated ammonium chloride solution and extracted with dichloromethane. The combined extracts were dried over magnesium sulfate, filtered, and concentrated to give the title compound for the next step.

Quelle