Reaktion #85835

ord-87e51de047cb434cb15f48580213071b

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2F)CC1
tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate
→
CC(C)(C)OC(=O)N1CCN(c2ccc(N)cc2F)CC1
tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate

Edukte

CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2F)CC1
tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate

Reagenzien

[Pd]
Pd/C

Lösungsmittel

CO
MeOH

Reaktionsbedingungen

Temperatur
20°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    FiltrationThe reaction was filtered
  2. 2
    Einengenconcentrated
  3. 3
    Sonstigeto give gray yellow oil

Vorschrift

To a solution of tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (5 mmol) in MeOH (30 mL) was added Pd/C (1 g), then the mixture was stirred for 18 hours at 20° C. under 1 atm. H2. The reaction was filtered and concentrated to give gray yellow oil. MS (m/z): 296 (M+H)+

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434726B2uspto-grants-2016_09