Reaktion #85834

Reaktionsgleichung

water

tert-butyl piperazine-1-carboxylate

K2CO3

1,2-difluoro-4-nitrobenzene

→

tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with EA (3×25 mL)
2. 2
   Waschenwashed with H2O (25 mL) and brine (25 mL)
3. 3
   Trocknendried over Na2SO4
4. 4
   Einengenconcentrated
5. 5
   Sonstigeto give yellow solid

Vorschrift

To a solution of tert-butyl piperazine-1-carboxylate (1120 mg, 6 mmol) in DMF (25 mL) was added K2CO3 (828 mg, 6 mmol) and 1,2-difluoro-4-nitrobenzene (795 mg, 5 mmol) at room temperature. The reaction was stirred at 80° C. for 24 hours. After that, the reaction was poured into 50 mL of water and extracted with EA (3×25 mL), washed with H2O (25 mL) and brine (25 mL), dried over Na2SO4 and concentrated to give yellow solid. MS (m/z): 226 (M−99)+

Quelle