Reaktion #85801

Reaktionsgleichung

2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

methanamine

DIPEA

→

title compound

N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenIt was then concentrated under reduced pressure
2. 2
   workup.ADDITIONthe residue was treated in EtOAc
3. 3
   SonstigeThe insoluble solid was removed by filtration
4. 4
   Einengenthe organic solution was concentrated under reduced pressure

Vorschrift

A mixture of 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (200 mg, 0.84 mmol), methanamine (277 mg, 8.4 mmol), and DIPEA (0.35 mL, 2.01 mmol) in dioxane (5 mL) was stirred at room temperature for 16 hours. It was then concentrated under reduced pressure, and the residue was treated in EtOAc. The insoluble solid was removed by filtration, and the organic solution was concentrated under reduced pressure to give the title compound.

Quelle