Reaktion #85733

Reaktionsgleichung

2,3-difluorobenzaldehyde

(R)-2-methylpropane-2-sulfinamide

→

(R,E)-N-(2,3-difluorobenzylidene)-2-methylpropane-2-sulfinamide

Ausbeute 93.0%

Lösungsmittel

DCE

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a oven dried round bottom flask
2. 2
   SonstigeReaction mixture
3. 3
   FiltrationThe reaction mixture was filtered through a celite pad
4. 4
   Waschenwashing solids with DCE
5. 5
   EinengenCombined filtrate was concentrated

Vorschrift

To a oven dried round bottom flask with stir bar was added 2,3-difluorobenzaldehyde (0.5 g, 3.52 mmol), (R)-2-methylpropane-2-sulfinamide (0.469 g, 3.87 mmol) and DCE (7.04 mL). To this mixture was then added Copper (II) Sulfate (0.842 g, 5.28 mmol). Reaction mixture heated in a preheated oil bath to 55° C. for 24 hr. The reaction mixture was filtered through a celite pad washing solids with DCE. Combined filtrate was concentrated to afford a viscous yellow oil of (R,E)-N-(2,3-difluorobenzylidene)-2-methylpropane-2-sulfinamide (0.8007 g, 3.26 mmol, 93% yield). MS m/z 246.1 (M+H)+; Rt-0.91 min.

Quelle