Reaktion #85701

Reaktionsgleichung

2-fluoro-4-(trifluoromethyl)benzaldehyde

(R)-2-methylpropane-2-sulfinamide

→

(R,E)-N-(2-fluoro-4-(trifluoromethyl)benzylidene)-2-methyl propane-2-sulfinamide

Ausbeute 95.0%

Lösungsmittel

DCE

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a oven dried round bottom flask
2. 2
   FiltrationThe reaction mixture was filtered through a pad celite
3. 3
   Waschenwashing the solids with DCE
4. 4
   EinengenThe filtrate was concentrated

Vorschrift

To a oven dried round bottom flask with stir bar was added 2-fluoro-4-(trifluoromethyl)benzaldehyde (5 g, 26.0 mmol), (R)-2-methylpropane-2-sulfinamide (3.47 g, 28.6 mmol) and DCE (52 mL). To this mixture was then added copper (II) sulfate (6.23 g, 39.0 mmol). The reaction mixture was heated in a preheated oil bath at 55° C. for 18 hours. The reaction mixture was filtered through a pad celite, washing the solids with DCE. The filtrate was concentrated to afford a viscous green oil of (R,E)-N-(2-fluoro-4-(trifluoromethyl)benzylidene)-2-methyl propane-2-sulfinamide (7.3 g, 24.7 mmol, 95% yield). Material was taken onto next step without further purification. 1H NMR (400 MHz, CDCl3) δ ppm 1.29 (s, 9H) 7.44 (d, J=10.08 Hz, 1H) 7.51 (d, J=8.27 Hz, 1H) 8.13 (t, J=7.46 Hz, 1H) 8.92 (s, 1H). LCMS m/z 296.0 (M+H)+, Rt 1.02 min.

Quelle