Reaktion #8567

Reaktionsgleichung

compound

(2S)-2-(2,3,4-Trifluoroanilino)-1-propanol

diethyl ethoxymethylenemalonate

→

title compound

Ausbeute 78.0%

Diethyl [2,3,4-trifluoro[(1S)-2-hydroxy-1-methylethyl]anilino]methylenemalonate

Ausbeute 78.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGFurther, it was stirred at the same temperature for 1.5 hour under reduced pressure
2. 2
   workup.WAITunder atmospheric pressure for additional 16 hours

Vorschrift

To the compound (103 mg) obtained in Example 51 was added diethyl ethoxymethylenemalonate (127 mg). Then the obtained mixture was stirred for 1 hour while heating to 100° C. under atmospheric pressure. Further, it was stirred at the same temperature for 1.5 hour under reduced pressure and then under atmospheric pressure for additional 16 hours. By analyzing reversed phase HPLC with the use of the compound of Example 63 as a specimen, the obtained product corresponded to 142 mg (78%) of the title compound.

Quelle