Reaktion #85535

ord-101cd446f63f4d5b893836a244db316c

Reaktionsgleichung

Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)Cl)cc2s1
2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride
NCCN1CCOCC1
2-morpholin-4-ylethylamine
CN1CCOCC1
NMM
→
Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)NCCN3CCOCC3)cc2s1
title compound
Ausbeute 44.2%
Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)NCCN3CCOCC3)cc2s1
2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid (2-morpholin-4-ylethyl)-amide
Ausbeute 44.2%

Edukte

Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)Cl)cc2s1
2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride
NCCN1CCOCC1
2-morpholin-4-ylethylamine
CN1CCOCC1
NMM

Reagenzien

Keine

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

the title compound (56 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride (100 mg, 0.30 mmol), 2-morpholin-4-ylethylamine (80 μL, 0.60 mmol) and PS-NMM (0.320 g, 0.60 mmol) in 5 mL of methanol. MS (m/z, ES+): 423.5 (M+1, 100%). Yield=43%.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434720B2uspto-grants-2016_09