Reaktion #85530

ord-4c0fe5e1decd4f07a2c8d6ded931ad2d

Reaktionsgleichung

Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)Cl)cc2s1
2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride
NCc1ccc(Cl)cc1
4-chlorobenzylamine
CN1CCOCC1
NMM
Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)NCc3ccc(Cl)cc3)cc2s1
title compound
Ausbeute 16.1%
Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)NCc3ccc(Cl)cc3)cc2s1
2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid 4-chlorobenzylamide
Ausbeute 16.1%

Lösungsmittel

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

the title compound (21 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride (100 mg, 0.30 mmol), 4-chlorobenzylamine (74 μL, 0.60 mmol) and PS-NMM (0.320 g, 0.60 mmol) in 5 mL of methanol. MS (m/z, ES+): 434.4 (Cl35 M+1, 100%), 436.4 (Cl37 M+1, 40%). Yield=16%.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434720B2uspto-grants-2016_09