Reaktion #85508

Reaktionsgleichung

4-nitrobenzenesulfonyl chloride

triethylamine

methylamine

→

4-nitrobenzenesulfonic acid methylamide

Lösungsmittel

Brine

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe reaction solution was extracted with ethyl acetate
2. 2
   TrocknenThe combined organic extracts were dried over sodium sulfate
3. 3
   Filtrationfiltered
4. 4
   Sonstigeevaporated

Vorschrift

To an ice cold solution of 4-nitrobenzenesulfonyl chloride (2.7 g, 12 mmol) and triethylamine (27 mmol) in 60 mL of dry THF was added methylamine (8 mL of a 2 M solution in THF, 16 mmol). The mixture was stirred at room temperature overnight. Brine was added and the reaction solution was extracted with ethyl acetate. The combined organic extracts were dried over sodium sulfate, filtered, and evaporated to yield 4-nitrobenzenesulfonic acid methylamide as an oil. The crude material was used in the subsequent reaction without further purification.

Quelle