Reaktion #85495

Reaktionsgleichung

N-methylbenzylamine

chloroacetyl chloride

→

title compound

Ausbeute 63.2%

N-benzyl-2-chloro-N-methylacetamide

Ausbeute 63.2%

Lösungsmittel

EtOAc

NaHCO3

—

hexanes

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe phases were separated
2. 2
   Waschenthe organic phase was washed with brine (5 mL)
3. 3
   Sonstigedried
4. 4
   Einengenconcentrated

Vorschrift

To a vigorously stirred suspension of N-methylbenzylamine (0.260 mL, 2 mmol) in EtOAc (3 mL) and 3 mL of saturated NaHCO3 solution was added chloroacetyl chloride (0.160 mL, 2 mmol). Effervescence was observed. Once gas production had ceased, the reaction mixture was diluted with hexanes (10 mL). The phases were separated and the organic phase was washed with brine (5 mL), dried and concentrated to yield ˜0.250 g of the title compound as an oil. The crude material was used in the subsequent step without further purification.

Quelle