Reaktion #85474

ord-e3e9d81bc0c74326998525d33caf09df

Reaktionsgleichung

CCOc1ncccc1C1(O)C(=O)Nc2cc(F)c(Cl)cc21
5-chloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one
O=C1Nc2ccccc2C1O
3-hydroxy-1,3-dihydroindol-2-one
COc1ccc(S(=O)(=O)Cl)c(OC)c1
2,4-dimethoxyphenylsulfonyl chloride
O=S(=O)(Cl)Cl
sulfonyl chloride
→
CCOc1ncccc1C1(N)C(=O)N(S(=O)(=O)c2ccc(OC)cc2OC)c2cc(F)c(Cl)cc21
3-Amino-5-chloro-1-(2,4-dimethoxyphenylsulfonyl)-3-(2-ethoxypyridin-3-yl)-6-fluoro-1,3-dihydroindol-2-one
CCOc1ncccc1C1(O)C(=O)Nc2cc(F)c(Cl)cc21
5-Chloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one

Edukte

CCOc1ncccc1C1(O)C(=O)Nc2cc(F)c(Cl)cc21
5-chloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one
O=C1Nc2ccccc2C1O
3-hydroxy-1,3-dihydroindol-2-one
COc1ccc(S(=O)(=O)Cl)c(OC)c1
2,4-dimethoxyphenylsulfonyl chloride
O=S(=O)(Cl)Cl
sulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

3-Amino-5-chloro-1-(2,4-dimethoxyphenylsulfonyl)-3-(2-ethoxypyridin-3-yl)-6-fluoro-1,3-dihydroindol-2-one was prepared in analogy to example 1.1 to 1.3 using 5-chloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one as 3-hydroxy-1,3-dihydroindol-2-one IV and 2,4-dimethoxyphenylsulfonyl chloride as sulfonyl chloride VII. 5-Chloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one was prepared in analogy to example a.1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434713B2uspto-grants-2016_09