Reaktion #85389

Reaktionsgleichung

potassium bicarbonate

(E)-2-(2-(Pyridin-3-yl)hydrazono)acetic acid hydrochloride

N-chlorosuccinimide

sodium carbonate

Methyl acrylate

→

desired product

Ausbeute 65.7%

Methyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate

Ausbeute 65.7%

Lösungsmittel

Water

ethyl acetate

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture stirred at 18° C
2. 2
   workup.WAITThe reaction temperature rose from 18 to 21° C. over 1 hour
3. 3
   workup.STIRRINGthe reaction was stirred for 20 hours
4. 4
   FiltrationThe mixture was filtered through Celite®
5. 5
   Extraktionthe filtrate was extracted with ethyl acetate (2×500 mL)
6. 6
   SonstigeThe organic layers were dried
7. 7
   Einengenconcentrated
8. 8
   SonstigeThe residue was purified by flash column chromatography

Vorschrift

(E)-2-(2-(Pyridin-3-yl)hydrazono)acetic acid hydrochloride (13.6 g, 64.1 mmol) was stirred in ethyl acetate (250 mL). N-chlorosuccinimide (17.9 g, 131 mmol) was added and the reaction stirred for 10 minutes. Methyl acrylate (35.2 mL, 385 mmol) was added followed by addition of potassium bicarbonate (19.4 g, 192 mmol). Water (0.05 mL) was added and the mixture stirred at 18° C. The reaction temperature rose from 18 to 21° C. over 1 hour and the reaction was stirred for 20 hours. Water (300 mL) and saturated aqueous sodium carbonate (˜100 mL) were added. The mixture was filtered through Celite® and the filtrate was extracted with ethyl acetate (2×500 mL). The organic layers were dried and concentrated. The residue was purified by flash column chromatography using 50-100% ethyl acetate/hexanes as eluent to afford the desired product as an orange oil (10.1 g, 62.5%): 1H NMR (400 MHz, CDCl3) δ 8.30 (dd, J=2.9, 0.7 Hz, 1H), 8.18 (dd, J=4.7, 1.4 Hz, 1H), 7.38 (ddd, J=8.4, 2.9, 1.4 Hz, 1H), 7.19 (ddd, J=8.5, 4.7, 0.7 Hz, 1H), 4.81 (dd, J=12.4, 6.9 Hz, 1H), 3.79 (s, 3H), 3.56 (dd, J=17.8, 12.4 Hz, 1H), 3.34 (dd, J=17.8, 6.9 Hz, 1H); ESIMS m/z 240 ([M+H]+).

Quelle