Reaktion #8538

Reaktionsgleichung

Methyl 2-(2,3,4-trifluoroanilino)propionate

lithium hydroxide

→

title compound

Ausbeute 99.7%

2-(2,3,4-Trifluoroanilino)propionic acid

Ausbeute 99.7%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat 0° C
2. 2
   Sonstigethe solvent was evaporated
3. 3
   workup.ADDITIONAfter adding water
4. 4
   Waschenthe residue was washed with chloroform
5. 5
   workup.ADDITIONNext, hydrochloric acid (6 mol/l) was slowly added to the aqueous layer until pH value
6. 6
   ExtraktionThen the aqueous layer was extracted with diisopropyl ether (IPE)
7. 7
   TrocknenThe organic layer was dried over anhydrous magnesium sulfate
8. 8
   Sonstigethe solvent was evaporated

Vorschrift

Methyl 2-(2,3,4-trifluoroanilino)propionate (46.64 g) was dissolved in methanol (130 ml) and an aqueous solution (3 mol/l; 100 ml) of lithium hydroxide was slowly added thereto at 0° C. After stirring at room temperature for 3 hours, the solvent was evaporated. After adding water, the residue was washed with chloroform. Next, hydrochloric acid (6 mol/l) was slowly added to the aqueous layer until pH value reached 1. Then the aqueous layer was extracted with diisopropyl ether (IPE). The organic layer was dried over anhydrous magnesium sulfate and then the solvent was evaporated to give the title compound (43.7 g) as colorless crystals.

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