Reaktion #8537

Reaktionsgleichung

2,3,4-Trifluoroaniline

pyruvic acid

hydrogen

→

title compound

Ausbeute 91.4%

2-(2,3,4-Trifluoroanilino)propionic acid

Ausbeute 91.4%

Lösungsmittel

IPA

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtering off Pd—C
2. 2
   Einengenthe obtained filtrate was concentrated under reduced pressure

Vorschrift

2,3,4-Trifluoroaniline (4.18 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under atmospheric pressure in a hydrogen atmosphere for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (5.69 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Quelle