Reaktion #8536

Reaktionsgleichung

2,3,4-Trifluoronitrobenzene

pyruvic acid

→

title compound

Ausbeute 96.0%

2-(2,3,4-Trifluoroanilino)propionic acid

Ausbeute 96.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtering off Pd—C
2. 2
   Einengenthe obtained filtrate was concentrated under reduced pressure

Vorschrift

2,3,4-Trifluoronitrobenzene (1.01 g) and pyruvic acid (0.75 g) were dissolved in methanol (8 ml). After adding 5% Pd—C (0.11 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 4.9 MPa (converted from 50 kgf/cm2) for 5 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.20 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Quelle