Reaktion #8535

Reaktionsgleichung

2,3,4-Trifluoronitrobenzene

pyruvic acid

→

title compound

Ausbeute 97.8%

2-(2,3,4-Trifluoroanilino)propionic acid

Ausbeute 97.8%

Lösungsmittel

IPA

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtering off Pd—C
2. 2
   Einengenthe obtained filtrate was concentrated under reduced pressure

Vorschrift

2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.09 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Quelle