Reaktion #8534

Reaktionsgleichung

2,3,4-Trifluoronitrobenzene

pyruvic acid

hydrogen

→

title compound

Ausbeute 98.1%

2-(2,3,4-Trifluoroanilino)propionic acid

Ausbeute 98.1%

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtering off Pd—C
2. 2
   Einengenthe obtained filtrate was concentrated under reduced pressure

Vorschrift

2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in isopropanol (IPA; 40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under atmospheric pressure in a hydrogen atmosphere for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.11 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Quelle