Reaktion #8531

Reaktionsgleichung

hydrochloric acid

2,3,4-Trifluoronitrobenzene

ethyl pyruvate

→

title compound

Ausbeute 97.9%

Ethyl 2-(2,3,4-trifluoroanilino)propionate

Ausbeute 97.9%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtering off Pd—C
2. 2
   Einengenthe obtained filtrate was concentrated under reduced pressure

Vorschrift

2,3,4-Trifluoronitrobenzene (1.01 g) and ethyl pyruvate (1.15 g) were dissolved in ethanol (8 ml). After adding 5% Pd—C (0.11 g) and conc. hydrochloric acid (0.03 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.38 g) was obtained as slightly yellow oily substance. Various spectral data of this product was identical with those obtained in Example 7.

Quelle