Reaktion #8528

Reaktionsgleichung

hydrogen

2,3,4-Trifluoronitrobenzene

methyl pyruvate

ethanol

magnesium sulfate

→

title compound

Ethyl 2-(2,3,4-trifluoroanilino)propionate

Lösungsmittel

ethyl acetate normal hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtering off Pd—C and magnesium sulfate
2. 2
   Einengenthe obtained filtrate was concentrated under reduced pressure
3. 3
   SonstigeThe residue thus obtained

Vorschrift

2,3,4-Trifluoronitrobenzene (3.54 g) and methyl pyruvate (2.32 g) were dissolved in ethanol (30 ml). After adding 5% Pd—C (2.0 g) and anhydrous magnesium sulfate (2.65 g), the mixture was stirred at 50° C. in a hydrogen atmosphere for 16 hours. After filtering off Pd—C and magnesium sulfate, the obtained filtrate was concentrated under reduced pressure. The residue thus obtained was subjected to silica gel column chromatography (ethyl acetate-normal hexane=1:4) to give the title compound (4.84 g) as a pale yellow oily substance.

Quelle