Reaktion #8527

Reaktionsgleichung

hydrogen

2,3,4-Trifluoroaniline

methyl pyruvate

magnesium sulfate

→

title compound

Ausbeute 95.3%

Methyl 2-(2,3,4-trifluoroanilino)propionate

Ausbeute 95.3%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtering off Pd—C and magnesium sulfate
2. 2
   Einengenthe obtained filtrate was concentrated under reduced pressure
3. 3
   SonstigeThe crystals thus precipitated
4. 4
   Filtrationwere filtered
5. 5
   Waschenwhile washing with hexane

Vorschrift

2,3,4-Trifluoroaniline (2.94 g) and methyl pyruvate (2.04 g) were dissolved in methanol (30 ml). After adding 5% Pd—C (2.0 g) and anhydrous magnesium sulfate (2.65 g), the mixture was stirred at 50° C. in a hydrogen atmosphere for 16 hours. After filtering off Pd—C and magnesium sulfate, the obtained filtrate was concentrated under reduced pressure. The crystals thus precipitated were filtered while washing with hexane. Thus the title compound (4.44 g) was obtained as slightly yellowish crystals. Various spectral data of this product was identical with those obtained in Example 5.

Quelle