Reaktion #8525

Reaktionsgleichung

2,3,4-trifluoroaniline

potassium carbonate

methyl (2R)-2-[(methanesulfonyl)oxy]propionate

→

title compound

Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn accordance with the process of Example 2, a condensation reaction

Vorschrift

In accordance with the process of Example 2, a condensation reaction was performed by using 2,3,4-trifluoroaniline (100 mg), potassium carbonate (188 mg), methyl (2R)-2-[(methanesulfonyl)oxy]propionate (78 mg) and tetrahexylammonium chloride (40 mg) to give the title compound as an oily substance. As the result of the analysis by reversed phase HPLC with the use of the compound of Example 1 as a specimen, the product corresponded to 38 mg (24%) of the title compound.

Quelle