Reaktion #8521

Reaktionsgleichung

trifluoromethyl phenyl sulfone tBuOK

trifluoromethyl phenyl sulfone tBuOK

methyl benzoate

iodobenzene

2,2,2-trifluoroacetophenone

→

α,α,α-trifluorotoluene

Ausbeute 26.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat about −50° C. to about −20° C

Vorschrift

The trifluoromethyl phenyl sulfone/tBuOK trifluoromethylation method can also be applied to other systems. For instance, methyl benzoate can be trifluoromethylated to generate 2,2,2-trifluoroacetophenone in 30% yield at about −50° C. to about −20° C. CF3Cu can be in situ generated with trifluoromethyl phenyl sulfone/tBuOK and copper iodide (CuI), and then further react with iodobenzene at 80° C. for 20 h to give α,α,α-trifluorotoluene in 26% yield.

Quelle