Reaktion #85140

ord-22f0738f677c45ddb74ad6d6bc38e640

Reaktionsgleichung

COc1cc(-c2cc(Cl)ccc2C#N)c(OCC(F)(F)F)cn1
4-chloro-2-[2-methoxy-5-(2,2,2-trifluoroethoxy)pyridin-4-yl]benzonitrile
Br.c1cc[nH+]cc1
pyridinium hydrobromide
N#Cc1ccc(Cl)cc1-c1cc(=O)[nH]cc1OCC(F)(F)F
4-Chloro-2-[2-oxo-5-(2,2,2-trifluoroethoxy)-1,2-dihydropyridin-4-yl]benzonitrile

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

168 mg (0.47 mmol) of 4-chloro-2-[2-methoxy-5-(2,2,2-trifluoroethoxy)pyridin-4-yl]benzonitrile and pyridinium hydrobromide were reacted according to General Method 3A. Yield: 112 mg (purity 92%, 67% of theory)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434690B2uspto-grants-2016_09