Reaktion #85135
ord-ded25a1437784d6fafb707e5b36c77fc
Reaktionsgleichung
4-chloro-2-[5-(difluoromethoxy)-2-methoxypyridin-4-yl]benzonitrile
pyridinium hydrobromide
→
4-Chloro-2-[5-(difluoromethoxy)-2-oxo-1,2-dihydropyridin-4-yl]benzonitrile
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Aufarbeitung
- 1SonstigeThe crude product was purified by flash chromatography (IR-50SI, dichloromethane/methanol 3-25%)
Vorschrift
230 mg (purity 80%, 0.59 mmol) of 4-chloro-2-[5-(difluoromethoxy)-2-methoxypyridin-4-yl]benzonitrile and pyridinium hydrobromide were reacted according to General Method 3A. The crude product was purified by flash chromatography (IR-50SI, dichloromethane/methanol 3-25%). Yield: 167 mg (95% of theory)