Reaktion #85122

ord-05f87568bc0245d6a91f81b9f62d23bc

Reaktionsgleichung

COc1cc(-c2cc(Cl)ccc2OC(F)F)c(OC)cn1
4-[5-chloro-2-(difluoromethoxy)phenyl]-2,5-dimethoxypyridine
Br.c1cc[nH+]cc1
pyridinium hydrobromide
COc1c[nH]c(=O)cc1-c1cc(Cl)ccc1OC(F)F
4-[5-Chloro-2-(difluoromethoxy)phenyl]-5-methoxypyridin-2(1H)-one

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

170 mg (purity 90%, 0.49 mmol) of 4-[5-chloro-2-(difluoromethoxy)phenyl]-2,5-dimethoxypyridine and pyridinium hydrobromide were reacted according to General Method 3A. Yield: 127 mg (87% of theory)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434690B2uspto-grants-2016_09