Reaktion #85028

Reaktionsgleichung

water dichloromethane

3,4-dihydro-2H-pyran

4-toluenesulphonic acid

6-methoxypyridin-3-ol

→

2-Methoxy-5-(tetrahydro-2H-pyran-2-yloxy)pyridine

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe aqueous phase was extracted with dichloromethane
2. 2
   TrocknenThe combined organic phases were dried (sodium sulphate)
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

10.1 g (119.9 mmol, 1.5 eq.) of 3,4-dihydro-2H-pyran and 1.4 g (8.0 mmol, 0.1 eq.) of 4-toluenesulphonic acid were added to a solution of 10.0 g (79.9 mmol) of 6-methoxypyridin-3-ol in 150 ml of dichloromethane, and the mixture was stirred at RT for 5 d. After addition of water/dichloromethane and phase separation, the aqueous phase was extracted with dichloromethane. The combined organic phases were dried (sodium sulphate), filtered and concentrated under reduced pressure. Yield: 17.3 g (100% of theory)

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