Reaktion #85019

ord-01797c5ca2164461bf7c29977e642fb8

Reaktionsgleichung

COc1c[nH]c(=O)cc1-c1cc(Cl)ccc1[N+](=O)[O-]
4-(5-chloro-2-nitrophenyl)-5-methoxypyridin-2(1H)-one
CC(Br)C(=O)O
2-bromopropanoic acid
→
COc1cn(C(C)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1[N+](=O)[O-]
2-[4-(5-Chloro-2-nitrophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]propanoic acid

Edukte

COc1c[nH]c(=O)cc1-c1cc(Cl)ccc1[N+](=O)[O-]
4-(5-chloro-2-nitrophenyl)-5-methoxypyridin-2(1H)-one
CC(Br)C(=O)O
2-bromopropanoic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeaccording to General Method 4A at 50° C

Vorschrift

115 mg (purity 85%, 0.35 mmol) of 4-(5-chloro-2-nitrophenyl)-5-methoxypyridin-2(1H)-one and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A at 50° C. Yield: 43 mg (35% of theory)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434690B2uspto-grants-2016_09