Reaktion #84967

Reaktionsgleichung

tert-butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]-3-(pyridin-4-yl)propanoate

TFA

→

2-[4-(2-Bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]-3-(pyridin-4-yl)propanoic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter work-up, the residue was triturated with diethyl ether
2. 2
   Filtrationthe solid was filtered off
3. 3
   Sonstigedried under reduced pressure

Vorschrift

1.7 g (purity 89%, 3.2 mmol) of tert-butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]-3-(pyridin-4-yl)propanoate (racemate) were hydrolysed with TFA according to General Method 6A. After work-up, the residue was triturated with diethyl ether and the solid was filtered off and dried under reduced pressure. Yield: 1.8 g (purity 76%, 99% of theory)

Quelle