Reaktion #84947

Reaktionsgleichung

4-bromopyridin-2(1H)-one

ethyl 2-bromo-3-phenylpropanoate

sodium hydride

lithium bromide

→

Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-phenylpropanoate

Reaktionsbedingungen

Vorschrift

544 mg (3.13 mmol) of 4-bromopyridin-2(1H)-one and 845 mg (3.3 mmol) of ethyl 2-bromo-3-phenylpropanoate (racemate) in the presence of 1.15 eq. of sodium hydride and 2.3 eq. of lithium bromide were reacted according to General Method 4C (stirred at 65° C. for 1.5 h). Yield: 572 mg (51% of theory)

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