Reaktion #8493

Reaktionsgleichung

HCl

2-[2-(4-fluorophenyl)ethyl]-5-fluorobenzonitrile

NaOH

H2O

→

cream-colored solid

Ausbeute 88.4%

2-[2-(4-Fluorophenyl)ethyl]-5-fluorobenzoic acid

Ausbeute 88.4%

Lösungsmittel

ethylene glycol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool
2. 2
   SonstigeThe cloudy mixture precipitated the desired product as a cream-colored solid
3. 3
   WaschenThis material was washed with H2O (3×20 mL)
4. 4
   Sonstigedried under vacuum (18 h, 25° C., 0.1 mm Hg)

Vorschrift

A mixture of 2-[2-(4-fluorophenyl)ethyl]-5-fluorobenzonitrile (2.12 g, 8.72 mmol, 1 equiv) and aq. NaOH (10N; 3.9 mL, 39.3 mmol, 4.5 equiv) in ethylene glycol (25 mL) was heated at 190° C. for 24 h. After allowing the mixture to cool, H2O (100 mL) was added followed by 12N HCl (8 mL). The cloudy mixture precipitated the desired product as a cream-colored solid. This material was washed with H2O (3×20 mL) and dried under vacuum (18 h, 25° C., 0.1 mm Hg) to provide 2.02 g (88.4%) of a cream-colored solid.

Quelle