Reaktion #84925

ord-3e219e54f5904e4bb01d3092674b116a

Reaktionsgleichung

CC(C(=O)O)n1ccc(-c2cc(Cl)ccc2Br)cc1=O
2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid
CC(C)(C)OC(=O)c1ccc(N)cc1
tert-butyl 4-aminobenzoate
→
CC(C(=O)Nc1ccc(C(=O)OC(C)(C)C)cc1)n1ccc(-c2cc(Cl)ccc2Br)cc1=O
tert-Butyl 4-({2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoate

Edukte

CC(C(=O)O)n1ccc(-c2cc(Cl)ccc2Br)cc1=O
2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid
CC(C)(C)OC(=O)c1ccc(N)cc1
tert-butyl 4-aminobenzoate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

153 mg (purity 93%, 0.4 mmol) of 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid (racemate) and 1.2 eq. of tert-butyl 4-aminobenzoate were reacted according to General Method 5A. Yield: 96 mg (44% of theory)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434690B2uspto-grants-2016_09