Reaktion #84917

ord-68e0b47f566a464c81190df14b1fef97

Reaktionsgleichung

C[Si](C)(C)C#Cc1ccc(Cl)cc1-c1cc[nH]c(=O)c1
4-{5-chloro-2-[(trimethylsilyl)ethynyl]phenyl}pyridin-2(1H)-one
CC(Br)C(=O)OC(C)(C)C
tert-butyl 2-bromopropanoate
→
CC(C(=O)OC(C)(C)C)n1ccc(-c2cc(Cl)ccc2C#C[Si](C)(C)C)cc1=O
tert-Butyl 2-[4-{5-chloro-2-[(trimethylsilyl)ethynyl]phenyl}-2-oxopyridin-1(2H)-yl]propanoate

Edukte

C[Si](C)(C)C#Cc1ccc(Cl)cc1-c1cc[nH]c(=O)c1
4-{5-chloro-2-[(trimethylsilyl)ethynyl]phenyl}pyridin-2(1H)-one
CC(Br)C(=O)OC(C)(C)C
tert-butyl 2-bromopropanoate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

125 mg (purity 91%, 0.38 mmol) of 4-{5-chloro-2-[(trimethylsilyl)ethynyl]phenyl}pyridin-2(1H)-one and 1.2 eq. of tert-butyl 2-bromopropanoate (racemate) were reacted at 80° C. according to General Method 4B. Yield: 56 mg (purity 89%, 31% of theory)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434690B2uspto-grants-2016_09