Reaktion #8490

Reaktionsgleichung

5-fluoro-2-methylbenzonitrile

N-bromosuccinimide

→

product

Ausbeute 102.0%

2-Bromomethyl-5-fluorobenzonitrile

Ausbeute 102.0%

Lösungsmittel

carbon tetrachloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 18 h
2. 2
   Filtrationfiltered through fritted glass
3. 3
   WaschenThe solid in the funnel was washed with carbon tetrachloride (3×50 mL)
4. 4
   Sonstigeevaporated to dryness under vacuum

Vorschrift

A mixture of 5-fluoro-2-methylbenzonitrile (10.0 g, 74.0 mmol), N-bromosuccinimide (NBS, 13.2 g, 74.0 mmol), benzoyl peroxide (0.2 g, 0.82 mmol), and carbon tetrachloride (100 mL) was refluxed for 18 h. The reaction mixture was then cooled to room temperature and filtered through fritted glass. The solid in the funnel was washed with carbon tetrachloride (3×50 mL) and evaporated to dryness under vacuum to provide 16.1 g, 102% yield of product.

Quelle