Reaktion #8481

Reaktionsgleichung

epichlorohydrin

product

2-[4-hydroxyphenyl]-8-methylimidazo[1,2-a]pyridine

potassium hydroxide

→

title compound

2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

Lösungsmittel

dichloromethane

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Waschenthe filtrate washed with water
3. 3
   Sonstigedried
4. 4
   Filtrationsodium sulfate filtered
5. 5
   Sonstigeevaporated

Vorschrift

The product of Step B (27 g) in methanol (500 mL) was treated with potassium hydroxide (14 g) and stirred at ambient temperature for 2 hours. To this solution was then added epichlorohydrin (9.4 mL) and the mixture stirred for an additional 48 hours. The reaction mixture was diluted with dichloromethane, filtered and the filtrate washed with water, dried, sodium sulfate filtered and evaporated to afford the title compound (18.2 g).

Quelle