Reaktion #84717

Reaktionsgleichung

(4S,5S)-2,2-dimethyl-5-((R)-1-phenylethylamino)-tetrahydro-2H-pyran-4-ol

hydrogen

hydrogen

→

title compound

Ausbeute 189.4%

(4S,5S)-5-amino-2,2-dimethyl-tetrahydro-2H-pyran-4-ol

Ausbeute 189.4%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter that, the mixture was filtered through a pad of celite
2. 2
   Einengenthe filtrate was concentrated

Vorschrift

A suspension mixture of (4S,5S)-2,2-dimethyl-5-((R)-1-phenylethylamino)-tetrahydro-2H-pyran-4-ol (1.0 g, 4.0 mmol) and 10% palladium on carbon (200 mg) in methanol (20 mL) was stirred at room temperature under 1 atm hydrogen atmosphere (hydrogen balloon) overnight. After that, the mixture was filtered through a pad of celite, and the filtrate was concentrated to get the title compound (1.1 g, crude) as a yellow oil, which was used directly for the next step without further purification.

Quelle