Reaktion #84712

Reaktionsgleichung

(4R,5R)-2,2-dimethyl-5-((R)-1-phenylethylamino)-tetrahydro-2H-pyran-4-ol

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title compound

Ausbeute 157.8%

(4R,5R)-5-amino-2,2-dimethyl-tetrahydro-2H-pyran-4-ol

Ausbeute 157.8%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter that, the mixture was filtered through a pad of celite
2. 2
   Einengenthe filtrate was concentrated

Vorschrift

A mixture of (4R,5R)-2,2-dimethyl-5-((R)-1-phenylethylamino)-tetrahydro-2H-pyran-4-ol (600 mg, 2.40 mmol) and 10% palladium on carbon (100 mg) in methanol (50 mL) was stirred at room temperature under hydrogenation overnight. After that, the mixture was filtered through a pad of celite, and the filtrate was concentrated to afford the title compound (550 mg, crude) as a yellow oil, which was used directly for the next step without further purification.

Quelle