Reaktion #8460

Reaktionsgleichung

sodium bicarbonate

product

2′-fluoro-4′-chloropropoxyacetophenone

bromine

→

title compound

alpha-bromo-2′-fluoro-4′-chloropropoxyacetophenone

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe organic layer was separated
2. 2
   WaschenThe aqueous layer was washed with a fresh portion of ether (40 mL)
3. 3
   WaschenThe combined organic layers were washed with a fresh portion of water (50 mL)
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Filtrationfiltered
6. 6
   Sonstigeevaporated

Vorschrift

A solution of the product of Step A (2.3 g) in ether (10 mL) was treated with bromine (0.51 mL) and the mixture stirred for approximately 17 hours. The mixture was slowly poured into saturated sodium bicarbonate solution (40 mL) and then the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (40 mL). The combined organic layers were washed with a fresh portion of water (50 mL), dried over magnesium sulfate, filtered and evaporated to give the title compound (3.1 g).

Quelle