Reaktion #84566

Reaktionsgleichung

4-(4-amino-2-fluorophenyl)morpholin-3-one

acetyl ketene

→

title compound

Ausbeute 61.4%

N-(3-fluoro-4-(3-oxomorpholino)phenyl)-3-oxobutanamide

Ausbeute 61.4%

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to rt
2. 2
   Einengenconcentrated in vacuo
3. 3
   SonstigeThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:4)

Vorschrift

A mixture of 4-(4-amino-2-fluorophenyl)morpholin-3-one (2.51 g, 11.9 mmol) and acetyl ketene (2.51 g, 29.9 mmol) in EtOAc (40 mL) was stirred at 80° C. for 24 h. The mixture was cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:4) to give the title compound as a yellow solid (2.15 g, 61%).

Quelle