Reaktion #84564

Reaktionsgleichung

1,2-difluoro-4-nitrobenzene

morpholin-3-one

K2CO3

→

title compound

Ausbeute 42.0%

4-(2-fluoro-4-nitrophenyl)morpholin-3-one

Ausbeute 42.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to rt
2. 2
   Filtrationfiltered
3. 3
   Einengenthe filtrate was concentrated in vacuo
4. 4
   SonstigeThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=3:1)

Vorschrift

A mixture of 1,2-difluoro-4-nitrobenzene (7.95 g, 50.0 mmol), morpholin-3-one (5.06 g, 50.0 mmol) and K2CO3 (13.82 g, 100 mmol) in DMF (80 mL) was stirred at 140° C. overnight. The mixture was cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=3:1) to give the title compound as a yellow solid (5.00 g, 42%).

Quelle