Reaktion #84552

Reaktionsgleichung

water

3-fluorophenol

ethyl 2-bromo-2-methylpropanoate

K2CO3

→

title compound

Ausbeute 47.1%

ethyl 2-(3-fluorophenoxy)-2-methylpropanoate

Ausbeute 47.1%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed overnight
2. 2
   ExtraktionThe resulting mixture was extracted with DCM (40 mL×2)
3. 3
   WaschenThe combined organic phases were washed with brine (40 mL×2)
4. 4
   Trocknendried over anhydrous Na2SO4
5. 5
   Einengenconcentrated in vacuo
6. 6
   SonstigeThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1)

Vorschrift

A mixture of 3-fluorophenol (3.36 g, 30.0 mmol), ethyl 2-bromo-2-methylpropanoate (8.78 g, 45.0 mmol) and K2CO3 (6.22 g, 45.0 mmol) in acetone (50 mL) was refluxed overnight. The mixture was cooled to rt and 60 mL of water was added. The resulting mixture was extracted with DCM (40 mL×2). The combined organic phases were washed with brine (40 mL×2), dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1) to give the title compound as colorless liquid (3.20 g, 47%).

Quelle