Reaktion #84545

Reaktionsgleichung

NH4OH

2-(cyclohexyloxy)acetyl chloride

→

title compound

Ausbeute 56.0%

2-(cyclohexyloxy)acetamide

Ausbeute 56.0%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with DCM (20 mL×3)
2. 2
   WaschenThe combined organic layers were washed with brine (20 mL×2)
3. 3
   Trocknendried over anhydrous Na2SO4
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To 15 mL of NH4OH (25-28%) was added a solution of 2-(cyclohexyloxy)acetyl chloride (1.01 g, 5.72 mmol) in DCM (2 mL) in an ice bath and the mixture was stirred at rt for 5 min and extracted with DCM (20 mL×3). The combined organic layers were washed with brine (20 mL×2), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a white solid (0.5 g, 56%).

Quelle