Reaktion #84538

Reaktionsgleichung

water

1,2-difluoro-4-nitrobenzene

2-morpholinoethanol

Cs2CO3

→

title compound

Ausbeute 76.5%

4-(2-(2-fluoro-4-nitrophenoxy)ethyl)morpholine

Ausbeute 76.5%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe resulting mixture was extracted with DCM (30 mL×2)
2. 2
   WaschenThe combined organic phases were washed with brine (30 mL×3)
3. 3
   Trocknendried over anhydrous Na2SO4
4. 4
   Einengenconcentrated in vacuo
5. 5
   SonstigeThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1)

Vorschrift

A mixture of 1,2-difluoro-4-nitrobenzene (1.0 g, 6.29 mmol), 2-morpholinoethanol (1.0 g, 7.62 mmol) and Cs2CO3 in DMF (10 mL) was stirred at 75° C. for 12 h. 30 mL of water was then added and the resulting mixture was extracted with DCM (30 mL×2). The combined organic phases were washed with brine (30 mL×3), dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1) to give the title compound as yellow oil (1.30 g, 76%).

Quelle