Reaktion #84512

Reaktionsgleichung

3-trifluoromethyl-4-morpholinoaniline

acetyl ketene

→

title compound

Ausbeute 75.0%

N-(3-trifluoromethyl-4-morpholinophenyl)-3-oxobutanamide

Ausbeute 75.0%

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to rt
2. 2
   Einengenconcentrated in vacuo
3. 3
   SonstigeThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)

Vorschrift

A mixture of 3-trifluoromethyl-4-morpholinoaniline (4.0 g, 16.2 mmol), EtOAc (30 mL) and acetyl ketene (2.73 g, 32.5 mmol) was stirred at 90° C. overnight. The mixture was cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a yellow solid (4.0 g, 75%).

Quelle