Reaktion #84510

Reaktionsgleichung

1-fluoro-4-nitro-2-(trifluoromethyl)benzene

morpholine

Et3N

→

title compound

Ausbeute 91.0%

4-(4-nitro-2-(trifluoromethyl)phenyl)morpholine

Ausbeute 91.0%

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture was then concentrated in vacuo
2. 2
   SonstigeThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)

Vorschrift

A mixture of 1-fluoro-4-nitro-2-(trifluoromethyl)benzene (4.18 g, 20.0 mmol), morpholine (2.09 g, 24.0 mmol), Et3N (6.07 g, 60.0 mmol) and EtOAc (30 mL) was stirred at rt for 5 h. The mixture was then concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a yellow solid (5.0 g, 91%).

Quelle